Well, this won't be as easily said than done. Moving a hard drive with no OS on it, just data, is one thing. Moving a drive that runs your OS is another. I think what you'll have to do is when you move the drive, you'll have to reformat and reinstall Windows. This is necessary because Windows keeps track of what hardware it is working with. If it detects that the hardware is radically different (i.e. if it's moved to a different computer), it won't work. So yes, you can move it, but not without a bit of work first.