Ok, do you know the name of the file ? if you do...then bootup to safe mode by pressing the f8 button repeatedly right after your comp. logo dissapears....
then scroll down to safe mode without networking...
once there go to the where the file is or where the icon is & right click it.....then click properties. then click on advanced.....and untic the check marks....then go back and click appy.
now go to the registy & delete it from there: to do this click start/run/ type regedit & hit enter.
this is the registry, now highlight MY COMPUTER & then click EDIT/ then scroll down to FIND ....
once there, put in the name of the file you want to delete & hit find....this will search the entire registry for that specific file. once it finds it highlight it & export it at the top by clicking file / scroll down to export.
now that you have a backup, delete it, then click FIND NEXT....this will continue the search til it finds another area where that file is....
continue as before doing the same thing over and over til it says (no more can be found)
your done, now it should be gone from all area's of your hhd. & now you can delete the backups, once you have tested your comp. to see if all is back to normal.