There's a lot of room in it and as I don't really care about cable management I, for the most part, just left them where they were. Since there is so much room they don't really block air flow much but if you want to run cables behind the motherboard or whatever (there's also a lot of space up top to tuck them in there too) then you can definitely do that without much trouble.
As for airflow, it's not bad really with just the two fans. I found temperatures stayed relatively low. More recently I added a fan sucking in air in the top left side vent to blow on the heatsink (it has a flat mounted fan so it sucks that air in too) as well as another mounted on the top pulling hot air out. Also another recommendation is to mount your powersupply with the intake fan (assuming there is one) pointing up because there is a space to pull in outside air (you'll see what I mean when you get your case).
My only issue is that I was never able to get the 2 USB ports mounted on the front to work but I think it has something to do with the motherboard I'm using. The top ones work fine though.