its possible, but what would be the point of having your applications running on a non SSD when they are the ones that you want to use. I've actually thought about this same thing, but it didn't make sense. I use my software to access my data, and if the data is on a non SSD, than its sort of pointless. You may get a slight boost in Window operations, but every time you go to run a program or game, the SSD will have to wait for the HDD.
best way i can desribe it only imagine that the tractor is a miata or something