SSD / Hard Drive hybrids right now are the norm for folks who can't afford the large capacity drives. I own several SSDs, two at home, one at work, and I use them all in the same regard.
OS / Main programs = SSD (Main programs being browsers, Office 2010, and at work, my work related apps, and at home, some of my smaller games)
Games / Media = Hard drive (Your media, things like mp3s and even movies say from Amazon or iTunes, don't need much to play back, so they'd be fine on a hard drive)
The drives I use are:
Corsair 120GB = Desktop at work, laptop at home
Intel 40GB = Netbook at home