Originally Posted by Bloodstalker999
With it being that old Could it be that the IRQ is taken by another componet thus not allowing the mouse to work?
Highly doubtful, being that IRQ 10 and 12 are available if no mouse or USB is detected or installed (can be exceptions). It may just be the mouse. Are you using a PS/2 to USB converter (or visa versa?)? It may be that component. Also, what version of Windows? 6 years old would put it anywhere in the Windows 98-ME/2000 erra.