You sure can. I found this for you:
Plug in the drive, turn it on, and connect it to your PC via its USB or FireWire cable. Windows XP should automatically detect it and install drivers. (Most enclosures are also plug-and-play with Windows 2000 and recent Mac versions, with drivers often available for other OSs.)
Next you'll need to partition and format it. Right-click My Computer and choose Manage. The Initialize and Convert Disk wizard should be visible; keep clicking Next and follow the prompts to initialize the drive. When that's finished, the Computer Management window appears. Click Disk Management on the left pane, then scroll down the lower right pane until the new drive appears, and right-click it. Choose New Partition, then choose Primary Partition from the next screen, and follow the prompts to format the drive. Use the NTFS file system rather than FAT32, unless you plan to use the drive with an old version of Windows (Windows 95/98/Me).