what do you mean making it work?? if it's an IDE hard drive and you have a board with only 1 IDE channel taken up by a cd drive, or 2. You have a few options:
1. Only 1 Optical - put the hdd as a slave on that IDE channel.
2. Buy a PCI card that will give you some more IDE channels.
You should really give some more information on what exactly your trying to accomplish, you shouldn't have any issues getting an older drive to work on a newer computer.