Nah, the most programs I'd have open would be ZoneAlarm, AVG, MSAS, TuneUp Mem Optimizer, MS Word XP, Firefox, Winamp (playing video in classic skin), MSNM, AIM, and YIM. And even then I still have quite a lot of RAM left.
I do do video-editing every now and then though...I dunno how much extra RAM would affect it though.