Nope.... done doom 3, hl2, halo,etc. all at highest settings... which, for me, is 1280x1040 (17"lcd) and with whatever else I can get. I can't max out the antilaising or whatever (I get some lag) but I can go, max, to 75% with no lag at all.
Macbook Pro and Logitech z5500s. All you really need.