I think the op is on about the balloon 'tips' that appear when you mouse over an item in the desktop.
-Click Start, click Run, type regedit, and then press ENTER.
-Locate the following subkey: HKEY_CURRENT_USER\Software\Microsoft\Windows\Curre ntVersion\Explorer\Advanced.
-Right-click the right side pane, create a new DWORD value, and then name it EnableBalloonTips.
-Double-click EnableBalloonTips, and then give it a value of 0.
-Close Registry Editor.
-Log off Windows, and then log back on.
Only do so if your confident with editing the registry.