common audio interference

[madanchi]

Hi I'm having a little issue, I know what the cause is roughly but not sure how to resolve it, if even possible. I'm recieving audio interference in my headphones as it uses a usb to be powered, I think the interference is originating from either my cpu/ram/gpu/motherboard.

It's your common screaching/hissing/buzzin interference people get when using on-board audio. Yeah, I disabled that btw.

Sound cards:
Creative Sound Blaster X-Fi 5.1
M-Audio Audiophile 2496

My Audiophile has no interference at all, I'm guessing because it has sound filters as it's an old professional card I hear, whereas the x-fi Sound Blaster is a good soundcard but doesn't have the filters.

If this is correct and/or if there is a possible fix, I'd love to hear it!