If you have the money, the BEST cooling solution that there is is thermo electric cooling, also known as PHASE CHANGE or PELITIER COOLING. Swifttech makes an excellent unit, capable of absorbing even the largest amounts of heat for some of the best cooling around. Here is a link to the heatsink needed.
Water cooling is very safe. You would have to exert a lot of force to puncture the silicon tubing that is used to facilitate the liquid. Also, most units u refill outside the tower, either in the front door area or a refil tank that sits far away from the tower. They are simple to use and not that dangerous. Dont use knives or sharp objects around the tubing or pump manifolds and you will be fine.
Then go to Thermal Electric solutions and then the type of processor you have, and that assembly. Then get a GOOD swiftech liquid cooling pump system and install them all carefully.
For another good cooling option, use what I am not using. My 4800+ never passes 38C full load with this fan on high blast. One downfall, this fan cooler is HUGE, so you need to make sure it will fit on your motherboard first. Check the compatibility list.