i highly doubt it seeing as how even NIS 2007 is having issues. if you have the CD, its going to be worth a shot, but i wouldn't get my hopes up too much if i were you.
just a heads up, if your going to tell someone not to use a product, explain why, or give a different program to try. kinda goes with the no product flaming rule.
[edit] i do agree with sypware banisher tho. there are better programs out there. my personal favorite is NOD32. It will work with both the 32 and 64 bit versions of vista.