Running the scan in safe mode won't make any difference.
The file in question is in your System Restore archive which your anti-virus software cannot access. It poses no threat to your system unless you use SR to roll back the Operating System to an earlier restore point.
To remove it, disable and then re-enable System Restore.
Click Start > Right click My Computer> Properties> System Restore and place a check next to the "Turn off System Restore" box.
Restart the machine to flush the restore points and then re-enable System Restore by removing the check from the "Turn off System Restore" box.
Then go to Start> All Programs> Accessories> System Tools> System Restore and create a new Restore Point.