Usually, you run multiple instances of the client that have been installed to different directories. It's a fairly interesting, yet somewhat complicated, install process.
How much power from the rest of the system is required for GPU folding?
Say, I wanted to run four 8800 GTS's (i don't, this is just theoretical), would a single core sempron 140 be enough with 1GB DDR3? or would I need more RAM, or the second core enabled?