I've heard that the Antec is an awesome case, but you have to clean out the dust constantly, and takes a while to do decent cable management. It's not a "sit it and forget it" kinda case.
Like I said, I don't have one, but I know people that do. I think they may have taken one or more off, either not enough airflow with them or they were noisy. Can't remember.
If you have the case next to you like I do, you would understand. If it's on the floor under your desk, of course it isn't a big deal. But I only have room for mine on my desk right next to the monitor. So the fans really get annoying.