So a friend has a bunch of crap on his computer. Trojans, spyware and the like. What else should he be doing besides using a virus scanner and spybot s&d.
Honestly....Save all the important files to an external (or a second hard drive) and reformat the computer. Its really the only way to get everything off.
You could use extra scanners and such but none are 100% chance of getting everything off.