What is the best....

i would say NOD32 or AVG, i have NOD32 on my desktop and AVG on my lappy and they are pretty good.
 
Does Anti-Vir work with vista, I have been using this for a while on XP
 
download and see if it does, i'm not sure because i'm still running XP and planning on staying that way for a while :p
 
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