No, unless you're benchmarking or overclocking. To the average, not, but, later on, in 2-3 years, when Amd is still going strong and Intel's cpu's are cracking down, you'll notice it. Plus, intel is coming out with yonah pretty soon. X2's are going to be here for a while. The m2 mobo will be new, but the dual cores will still be up there. The D is just two prescott cores stuck together. The x2 is a totally different set up. A more mature cpu. yes, intel does suck at dual core technology. You'll notice in the long run. And, plus, it does depend on what you do. If you game, you'll definitely notice a difference. Oh yeah. You betcha. Amd's own on-die memory controller makes all the difference. Believe me here. I've owned intel's all my life until this comp. My 3.2ghz pent. 4 with 1g of ram, 200gb hd, basically the same setup as this comp, ran MUCH slower than my amd right now. And games are unbelieable. Trust me.... the .2 ghz isn't a big difference to the average user, but more advanced.. yes... hope this helps..