yes you can transfer the drive to a new case with no problem. The silver styling on the front is removable, so if the drive doesn't fit in the case, you can always unclip the facia. It won't look as good, but it will still work. as Lurkswithin says, you will need to make sure the jumber settings are correct, but even a drooling vegetable can do this. 1 master and 1 slave, simple